This paper examines the Impact of Macroeconomic Variables on the Return on Assets (ROA) of selected Commercial Banks in India for the period of 2018-2024. The study uses secondary quantitative data extracted from annual financial reports of the banks from the period investigated. The study employs multivariate linear regression to determine the relationship between ROA and three independent variables, namely Real Gross Domestic Product (GDP) Growth Rate, Inflation Rate, and Unemployment Rate.